Subthalamic Activity During Diphasic Dyskinesias in Parkinson's Disease
Identifieur interne : 000F76 ( Main/Exploration ); précédent : 000F75; suivant : 000F77Subthalamic Activity During Diphasic Dyskinesias in Parkinson's Disease
Auteurs : Manuel Alegre [Espagne] ; Jon Lopez-Azcarate [Espagne] ; Fernando Alonso-Frech [Espagne] ; Maria C. Rodriguez-Oroz [Espagne] ; Miguel Valencia [Espagne] ; Jorge Guridi [Espagne] ; Julio Artieda [Espagne] ; Jose A. Obeso [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood. Methods: We analyzed local field potentials recorded from the subthalamic nucleus in 7 Parkinson's disease (PD) patients who showed typical diphasic dyskinesias during postoperative recordings through a deep brain stimulation electrode. The evolution of the different oscillatory activities related to the onset and end of diphasic dyskinesias was studied by windowed fast Fourier transforms. Results: Typical "off"-state beta activity disappeared with the onset of diphasic dyskinesias, whereas gamma activity was absent or minimal until their end. Theta activity during diphasic dyskinesias was similar to that observed during peak-dose dyskinesias. Conclusions: From a neurophysiological viewpoint, patients exhibited oscillatory activity typical of the "on" medication state during diphasic dyskinesias. The minimal presence of gamma activity during diphasic dyskinesias, however, suggests that this "on" state might be incomplete or limited to dopaminergic mechanisms affecting the lower limbs.
Affiliations:
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Rodriguez-Oroz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurosciences Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology and Neurosurgery, Clínica Universidad de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Valencia, Miguel" sort="Valencia, Miguel" uniqKey="Valencia M" first="Miguel" last="Valencia">Miguel Valencia</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurosciences Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology and Neurosurgery, Clínica Universidad de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Artieda, Julio" sort="Artieda, Julio" uniqKey="Artieda J" first="Julio" last="Artieda">Julio Artieda</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurosciences Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neurophysiology Section, Clínica Universidad de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurosciences Area, CIMA, University of Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology and Neurosurgery, Clínica Universidad de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dyskinesia</term><term>Field potential</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Noyau sousthalamique</term><term>Potentiel champ</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood. Methods: We analyzed local field potentials recorded from the subthalamic nucleus in 7 Parkinson's disease (PD) patients who showed typical diphasic dyskinesias during postoperative recordings through a deep brain stimulation electrode. The evolution of the different oscillatory activities related to the onset and end of diphasic dyskinesias was studied by windowed fast Fourier transforms. Results: Typical "off"-state beta activity disappeared with the onset of diphasic dyskinesias, whereas gamma activity was absent or minimal until their end. Theta activity during diphasic dyskinesias was similar to that observed during peak-dose dyskinesias. Conclusions: From a neurophysiological viewpoint, patients exhibited oscillatory activity typical of the "on" medication state during diphasic dyskinesias. The minimal presence of gamma activity during diphasic dyskinesias, however, suggests that this "on" state might be incomplete or limited to dopaminergic mechanisms affecting the lower limbs.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Alegre, Manuel" sort="Alegre, Manuel" uniqKey="Alegre M" first="Manuel" last="Alegre">Manuel Alegre</name></noRegion><name sortKey="Alegre, Manuel" sort="Alegre, Manuel" uniqKey="Alegre M" first="Manuel" last="Alegre">Manuel Alegre</name><name sortKey="Alonso Frech, Fernando" sort="Alonso Frech, Fernando" uniqKey="Alonso Frech F" first="Fernando" last="Alonso-Frech">Fernando Alonso-Frech</name><name sortKey="Artieda, Julio" sort="Artieda, Julio" uniqKey="Artieda J" first="Julio" last="Artieda">Julio Artieda</name><name sortKey="Artieda, Julio" sort="Artieda, Julio" uniqKey="Artieda J" first="Julio" last="Artieda">Julio Artieda</name><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><name sortKey="Lopez Azcarate, Jon" sort="Lopez Azcarate, Jon" uniqKey="Lopez Azcarate J" first="Jon" last="Lopez-Azcarate">Jon Lopez-Azcarate</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><name sortKey="Valencia, Miguel" sort="Valencia, Miguel" uniqKey="Valencia M" first="Miguel" last="Valencia">Miguel Valencia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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